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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemopreventive Effects of (-)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

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Barbosa, Lilian C. [1] ; Furtado, Ricardo A. [1] ; Bertanha, Humberto C. C. [1] ; Tomazella, Iara M. [1] ; Costa, Eveline S. [1] ; Bastos, Jairo K. [2] ; Andrade e Silva, Marcio L. [1] ; Tavares, Denise C. [1]
Total Authors: 8
[1] Univ Franca, BR-14404600 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Natural Products; v. 77, n. 10, p. 2312-2315, OCT 2014.
Web of Science Citations: 4

(-)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (-)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4-5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay. (AU)

FAPESP's process: 08/02211-0 - Evaluation of rosmarinic acid effect on DNA damage in in vivo and in vitro mammalian cells and on rats colon carcinogenesis
Grantee:Ricardo Andrade Furtado
Support type: Scholarships in Brazil - Master