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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis

Texto completo
Autor(es):
Rolim, Ana Luiza R. [1] ; Lindsey, Susan C. [1] ; Kunii, Ilda S. [1] ; Crispim, Felipe [1] ; Moises, Regina Celia M. S. [1] ; Maciel, Rui M. B. [1] ; Dias-da-Silva, Magnus R. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Med, Lab Mol & Translat Endocrinol, BR-04039032 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF MOLECULAR ENDOCRINOLOGY; v. 53, n. 2, p. 295-301, OCT 2014.
Citações Web of Science: 2
Resumo

Thyrotoxicosis is the most common cause of the acquired flaccid muscle paralysis in adults called thyrotoxic periodic paralysis (TPP) and is characterised by transient hypokalaemia and hypophosphataemia under high thyroid hormone levels that is frequently precipitated by carbohydrate load. The sulphonylurea receptor 1 (SUR1 (ABCC8)) is an essential regulatory subunit of the beta-cell ATP-sensitive K+ channel that controls insulin secretion after feeding. Additionally, the SUR1 Ala1369Ser variant appears to be associated with insulin sensitivity. We examined the ABCC8 gene at the single nucleotide level using PCR-restriction fragment length polymorphism (RFLP) analysis to determine its allelic variant frequency and calculated the frequency of the Ala1369Ser C-allele variant in a cohort of 36 Brazilian TPP patients in comparison with 32 controls presenting with thyrotoxicosis without paralysis (TWP). We verified that the frequency of the alanine 1369 C-allele was significantly higher in TPP patients than in TWP patients (61.1 vs 34.4%, odds ratio (OR)=3.42, P=0.039) and was significantly more common than the minor allele frequency observed in the general population from the 1000 Genomes database (61.1 vs 29.0%, OR=4.87, P<0.005). Additionally, the C-allele frequency was similar between TWP patients and the general population (34.4 vs 29%, OR=1.42, P=0.325). We have demonstrated that SUR1 alanine 1369 variant is associated with allelic susceptibility to TPP. We suggest that the hyperinsulinaemia that is observed in TPP may be linked to the ATP-sensitive K+/SUR1 alanine variant and, therefore, contribute to the major feedforward precipitating factors in the pathophysiology of TPP. (AU)

Processo FAPESP: 10/51547-1 - Carcinoma Medular de Tiroide hereditário: percepção e atitude de pacientes, familiares e profissionais de saúde sobre questões bioéticas
Beneficiário:Rui Monteiro de Barros Maciel
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 06/60402-1 - Carcinoma medular da tiróide: revisitação à clínica, à biologia molecular, à bioquímica e à biologia do desenvolvimento depois dos achados da genética molecular
Beneficiário:Rui Monteiro de Barros Maciel
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 11/20747-8 - Investigação clínica, bioquímica e molecular da paralisia periódica tirotóxica
Beneficiário:Magnus Régios Dias da Silva
Linha de fomento: Auxílio à Pesquisa - Regular