Synthesis, Characterization, and Antifungal Activities of Amphiphilic Derivatives of Diethylaminoethyl Chitosan against Aspergillus flavus

Autor(es)

Gabriel, Juliana dos Santos ^[1] ; Tiera, Marcio Jose ^[1] ; de Oliveira Tiera, Vera Aparecida ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, IBILCE, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Agricultural and Food Chemistry; v. 63, n. 24, p. 5725-5731, JUN 24 2015.
• Citações Web of Science: 18

Resumo

Amphiphilic derivatives of diethylaminoethyl chitosan (DEAE-CH) were synthesized using a two-step process involving initial substitution with diethylaminoethyl (DEAE) groups followed by reductive amination with dodecylaldehyde. The synthesized derivatives were characterized by H-1 NMR, gel permeation, and FTIR. The associative behaviors of these compounds in aqueous solution were studied using fluorescence spectroscopy, whereas their antifungal activities against Aspergillus flavus were evaluated in terms of mycelial growth. The effects of deacetylated chitosans and their derivatives on the mycelial growth of A. flavus were evaluated at several polymer concentrations (0.05-1.0 g/L), and the results were compared. The inhibition Indices of the deacetylated chitosans increased with increasing M-w (16.9 kDa < 176 kDa < 517.7 kDa); however, derivatives with a combination of either a high molecular weight (M-w) and low hydrophobicity or a low M-w and high hydrophobicity were the most effective in inhibiting the in vitro radial growth of A. flavus. (AU)

• Processo FAPESP: 10/13942-6 - Síntese, caracterização e estudo de derivados anfifílicos catiônicos de quitosana como biofungicidas
• Beneficiário: Juliana dos Santos Gabriel
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/03619-9 - Biofungicidas: síntese e caracterização de derivados anfifílicos de quitosana para aplicação contra fungos do gênero Aspergillus
• Beneficiário: Vera Aparecida de Oliveira Tiera
• Modalidade de apoio: Auxílio à Pesquisa - Regular