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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, Characterization, and Antifungal Activities of Amphiphilic Derivatives of Diethylaminoethyl Chitosan against Aspergillus flavus

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Author(s):
Gabriel, Juliana dos Santos [1] ; Tiera, Marcio Jose [1] ; de Oliveira Tiera, Vera Aparecida [1]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ UNESP, IBILCE, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Agricultural and Food Chemistry; v. 63, n. 24, p. 5725-5731, JUN 24 2015.
Web of Science Citations: 18
Abstract

Amphiphilic derivatives of diethylaminoethyl chitosan (DEAE-CH) were synthesized using a two-step process involving initial substitution with diethylaminoethyl (DEAE) groups followed by reductive amination with dodecylaldehyde. The synthesized derivatives were characterized by H-1 NMR, gel permeation, and FTIR. The associative behaviors of these compounds in aqueous solution were studied using fluorescence spectroscopy, whereas their antifungal activities against Aspergillus flavus were evaluated in terms of mycelial growth. The effects of deacetylated chitosans and their derivatives on the mycelial growth of A. flavus were evaluated at several polymer concentrations (0.05-1.0 g/L), and the results were compared. The inhibition Indices of the deacetylated chitosans increased with increasing M-w (16.9 kDa < 176 kDa < 517.7 kDa); however, derivatives with a combination of either a high molecular weight (M-w) and low hydrophobicity or a low M-w and high hydrophobicity were the most effective in inhibiting the in vitro radial growth of A. flavus. (AU)

FAPESP's process: 10/13942-6 - Synthesis, characterization and study of cationic amphiphilic derivatives of chitosan as biofungicides
Grantee:Juliana dos Santos Gabriel
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/03619-9 - Biofungicides: synteses and characterization anphiphilic derivatives of chitosan for application against Aspergillus genus species
Grantee:Vera Aparecida de Oliveira Tiera
Support Opportunities: Regular Research Grants