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"Biopolymer Films based on Amphiphilic Derivatives of Chitosan as Antimicrobial Agents: Applications and Mode of Action"


This research project aims at the development of an antimicrobial agent for the preservation of grains, fruits and nuts, contributing to improve the competitiveness of Brazilian agribusiness, regarding the aspects of food safety and quality, with possible application on the conservation of commodities of high importance to the Brazilian trade balance. The proposal is grounded on an amphiphilic biofungicide (Patent No BR102012023859) based on the polysaccharide chitosan. The project focuses on optimizing the composition with minimal modifications to improve its antimicrobial activity while maintaining the biocompatibility and non-toxic character. The project has the collaboration of EMBRAPA instrumentation. The design involves steps of synthesis and characterization, in vitro tests against microorganisms, as well as the preparation and characterization of films for use in grains, fruits and nuts. The studies will focus on microorganisms that impact the conservation of internal trade products as well as those intended for foreign trade. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS, AMANDA MANCHINI; DOS SANTOS CABRERA, MARCIA PEREZ; FURUYAMA LIMA, ALINE MARGARETE; TABOGA, SEBASTIAO ROBERTO; LEITE VILAMAIOR, PATRICIA SIMONE; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Insights on the antifungal activity of amphiphilic derivatives of diethylaminoethyl chitosan against Aspergillus flavus. Carbohydrate Polymers, v. 196, p. 433-444, . (16/15736-0, 14/08372-7)
RODRIGUES SANTOS ALVES, ANNA CAROLINA; FURUYAMA LIMA, ALINE MARGARETE; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Biopolymeric Films of Amphiphilic Derivatives of Chitosan: A Physicochemical Characterization and Antifungal Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 17, . (16/15736-0)
CUNHA, OTAVIO DA MATA; FURUYAMA LIMA, ALINE MARGARETE; GARRIDO ASSIS, ODILIO BENEDITO; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Amphiphilic diethylaminoethyl chitosan of high molecular weight as an edible film. International Journal of Biological Macromolecules, v. 164, p. 3411-3420, . (17/13762-7, 16/15736-0)

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