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Biofungicides: synteses and characterization anphiphilic derivatives of chitosan for application against Aspergillus genus species


The search for natural antimicrobial agents is a new way to inhibit the growth of microorganisms including bacteria, virus and fungus. In this subject the polysaccharide chitosan has been shown very attractive for the food industry aiming to provide a safe feeding. The antimicrobial activity of chitosan depends on various parameters as the groups attached to the polymer chain, molecular weight and physics factors as temperature, pH, ionic strength, the targeted microorganism and the environment in which it is applied. Previous studies in our group showed that besides electrostatic interactions hydrophobic interactions may provide an improved fungicidal/fungistatic activity. In the present project we propose the synthesis and characterization of new amphiphilic derivatives of chitosan aiming to select effective fungicides against Aspergillus flavus and Aspergillus parasictus, which are known contaminants of peanuts and other seeds. The metabolic activity of fungi growth with humidity and besides, Brazil nut and other smoked products may be affected by these fungi as well. Therefore, the main objective of this project is to select effective biofungicides to control the growth of these fungi. In order to reach this goal we propose the modification of the chitosan structure by attaching to the main chain hydrophobic and cationic or anionic hydrophilic groups looking for optimize the antifungal activity. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, DANUBIA BATISTA; NASARIO, FABIO DOMINGUES; SILVA-GONCALVES, LAIZ COSTA; DE OLIVEIRA TIERA, VERA APARECIDA; ARCISIO-MIRANDA, MANOEL; TIERA, MARCIO JOSE; DOS SANTOS CABRERA, MARCIA PEREZ. Chitosan derivatives targeting lipid bilayers: Synthesis, biological activity and interaction with model membranes. Carbohydrate Polymers, v. 181, p. 1213-1223, FEB 1 2018. Web of Science Citations: 6.
GABRIEL, JULIANA DOS SANTOS; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Synthesis, Characterization, and Antifungal Activities of Amphiphilic Derivatives of Diethylaminoethyl Chitosan against Aspergillus flavus. Journal of Agricultural and Food Chemistry, v. 63, n. 24, p. 5725-5731, JUN 24 2015. Web of Science Citations: 18.
FELIX VIEGAS DE SOUZA, RICCHARD HALLAN; TAKAKI, MIRELLI; PEDRO, RAFAEL DE OLIVEIRA; GABRIEL, JULIANA DOS SANTOS; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA AP. Hydrophobic Effect of Amphiphilic Derivatives of Chitosan on the Antifungal Activity against Aspergillus flavus and Aspergillus parasiticus. Molecules, v. 18, n. 4, p. 4437-4450, APR 2013. Web of Science Citations: 11.
PEDRO, RAFAEL DE OLIVEIRA; TAKAKI, MIRELLE; CASTILHO GORAYE, TERESA CRISTINA; DEL BIANCHI, VANILDO LUIZ; THOMEO, JOAO CLAUDIO; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Synthesis, characterization and antifungal activity of quaternary derivatives of chitosan on Aspergillus flavus. MICROBIOLOGICAL RESEARCH, v. 168, n. 1, p. 50-55, 2013. Web of Science Citations: 33.

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