Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries

Autor(es)

Baldini Cardoso, Cristiane de Almeida ^[1] ; Lacerda, Bianca ^[1] ; Barros Mangueira, Dayane Franco ^[2] ; Charone, Senda ^[1] ; Kaneshiro Olympio, Kelly Polido ^[1] ; Magalhaes, Ana Carolina ^[1] ; Pessan, Juliano Pelim ^[3] ; Vilhena, Fabians Vieira ^[1] ; Sampaio, Fabio Correia ^[2] ; Rabelo Buzalaf, Marilia Afonso ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil

^[2] Univ Fed Paraiba, Dept Clin & Social Dent, BR-58051900 Joao Pessoa, PB - Brazil

^[3] Univ Estadual Paulista, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 60, n. 1, p. 23-28, JAN 2015.
• Citações Web of Science: 5

Resumo

Objective: This study attempted to clarify the mechanisms of action of fluoridated acidic liquid dentifrices against dental caries. Design: In the in vitro leg, enamel specimens were submitted to a pH-cycling model, treated with distinct dentifrices (0, 550 mu gF/g pH 4.5 and pH 7.0, 1100 or 5000 mu gF/g pH 7.0) and analyzed using hardness. Alkali-soluble fluoride (F) deposition was quantified on pre-demineralized specimens treated with the dentifrices. In the clinical leg, 2-to-4-year-old children who had been using liquid dentifrices for 6 months (550 mu gF/g pH 4.5 or pH 7.0 or 1100 mu gF/g pH 7.0) had their plaque samples collected 5 and 60 min after the last brushing. Fluoride uptake in whole plaque was evaluated. Results: The reduction of the pH had a partial preventive effect on subsurface hardness loss only. {[}F] had a significant influence on the deposition of fluoride, surface and subsurface hardness loss. In vivo, the reduction of the pH was able to significantly increase plaque F uptake, leading to similar levels as those found for the neutral dentifrice containing twice {[}F]. Conclusion: The results obtained from in vitro studies whose design does not include the presence of dental plaque should be interpreted with caution. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/58402-9 - Efeito do pH, da consistência e da concentração de flúor presente em dentifrícios líquidos no controle de cárie em áreas fluoretadas e não fluoretadas: estudos clínicos randomizados
• Beneficiário: Fabiano Vieira Vilhena
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE
• Processo FAPESP: 10/11916-8 - Avaliação do efeito de dentifrícios experimentais na forma de gel, com crescentes concentrações de flúor, acidulados ou neutros, sobre a desmineralização do esmalte dentário bovino in vitro
• Beneficiário: Bianca Milo Lacerda
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/01944-4 - Efeito do pH e da concentração de flúor presente em dentifrícios líquidos no controle de cárie em área fluoretada: estudo clínico randomizado
• Beneficiário: Cristiane de Almeida Baldini Cardoso
• Modalidade de apoio: Bolsas no Brasil - Doutorado