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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries

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Author(s):
Baldini Cardoso, Cristiane de Almeida [1] ; Lacerda, Bianca [1] ; Barros Mangueira, Dayane Franco [2] ; Charone, Senda [1] ; Kaneshiro Olympio, Kelly Polido [1] ; Magalhaes, Ana Carolina [1] ; Pessan, Juliano Pelim [3] ; Vilhena, Fabians Vieira [1] ; Sampaio, Fabio Correia [2] ; Rabelo Buzalaf, Marilia Afonso [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil
[2] Univ Fed Paraiba, Dept Clin & Social Dent, BR-58051900 Joao Pessoa, PB - Brazil
[3] Univ Estadual Paulista, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 60, n. 1, p. 23-28, JAN 2015.
Web of Science Citations: 5
Abstract

Objective: This study attempted to clarify the mechanisms of action of fluoridated acidic liquid dentifrices against dental caries. Design: In the in vitro leg, enamel specimens were submitted to a pH-cycling model, treated with distinct dentifrices (0, 550 mu gF/g pH 4.5 and pH 7.0, 1100 or 5000 mu gF/g pH 7.0) and analyzed using hardness. Alkali-soluble fluoride (F) deposition was quantified on pre-demineralized specimens treated with the dentifrices. In the clinical leg, 2-to-4-year-old children who had been using liquid dentifrices for 6 months (550 mu gF/g pH 4.5 or pH 7.0 or 1100 mu gF/g pH 7.0) had their plaque samples collected 5 and 60 min after the last brushing. Fluoride uptake in whole plaque was evaluated. Results: The reduction of the pH had a partial preventive effect on subsurface hardness loss only. {[}F] had a significant influence on the deposition of fluoride, surface and subsurface hardness loss. In vivo, the reduction of the pH was able to significantly increase plaque F uptake, leading to similar levels as those found for the neutral dentifrice containing twice {[}F]. Conclusion: The results obtained from in vitro studies whose design does not include the presence of dental plaque should be interpreted with caution. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/58402-9 - Effect of pH, consistency and concentration of fluoride in liquid dentifrices for caries control in fluoridated and non fluoridated areas: randomized clinical trials
Grantee:Fabiano Vieira Vilhena
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
FAPESP's process: 10/11916-8 - Effect of experimental gel dentifrices, with crescent F concentrations, acidulate or neutral, on bovine enamel demineralization in vitro
Grantee:Bianca Milo Lacerda
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/01944-4 - Effect of pH and fluoride concention of liquid dentifrices, on caries control in a fluoridated area: a randomized clinical trial
Grantee:Cristiane de Almeida Baldini Cardoso
Support Opportunities: Scholarships in Brazil - Doctorate