Advanced search
Start date

Effect of fluoride from dentifrice on the reduction of demineralization of fluorotic enamel

Grant number: 16/24190-1
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2017
Effective date (End): June 15, 2018
Field of knowledge:Health Sciences - Dentistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Jaime Aparecido Cury
Grantee:Luma Fabiane Almeida
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


It is still discussed if fluoride incorporated in enamel during its formation (pre-eruptive) could strength fluorotic enamel against caries. On other hand, we have recently shown in vitro that dental enamel with mild/moderate fluorosis is less resistant to demineralization than sound enamel. However, in this work the recognized local effect of fluoride (post-eruptive) of daily ingestion of fluoridated water or brushing teeth with fluoridated dentifrices was not simulated. Therefore, the aim of the present study is to evaluate if the fluoride from dentifrices could compensate greater susceptibility of fluorotic enamel to demineralization. Thus, an in vitro study with factorial design will be carried out and the factors under evaluation will be: Fluorosis in five levels, (TF 0, 1, 2, 3 and 4, classified by Thyustrup and Fejerskov index) and dentifrices in two levels, non-fluoride (placebo) and fluoridated (1,100 µg F/g as NaF). Twenty human teeth from each TF will be use. From each tooth, 2 enamel slabs will be obtained (4x3x2 mm), which will be paired within the two treatments. Half of the anatomic surface of the slabs will be protected with nail varnish to determine the baseline values of hypomineralization area and fluoride concentration. The slabs will be submitted to a pH cycling model simulating a high cariogenic challenge, and twice a day they will be treated with one of the dentifrices. At the end of 10 days of pH cycling regimen, the area of caries lesion and enamel fluoride concentration will be determined. We have hypothesized that fluoride from dentifrice should cancel the higher susceptibility of fluorotic teeth to the caries process. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA, LUMA FABIANE; MARIN, LINA MARIA; MARTINEZ-MIER, ESPERANZA ANGELES; CURY, JAIME APARECIDO. Fluoride Dentifrice Overcomes the Lower Resistance of Fluorotic Enamel to Demineralization. Caries Research, v. 53, n. 5, p. 567-575, 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: