Autor(es)

Reimer, Adriano Edgar ^{[1, 2]} ; de Oliveira, Amanda Ribeiro ^{[2, 3]} ; Diniz, Juliana Belo ^[4] ; Hoexter, Marcelo Queiroz ^[4] ; Chiavegatto, Silvana ^[5] ; Brandao, Marcus Lira ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Neuropsicofarmacol, BR-14090901 Ribeirao Preto, SP - Brazil

^[2] Inst Neurociencias & Comportamento, Ribeirao Preto - Brazil

^[3] Univ Fed Sao Carlos, Ctr Educcacao & Ciencias Humanas, Grp Psicobiol, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Psiquiatria, BR-14090901 Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-14090901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 292, p. 370-380, OCT 1 2015.
• Citações Web of Science: 10

Resumo

Individual differences are important biological predictors for reactivity to stressful stimulation. The extent to which trait differences underlie animal's reactions to conditioned and unconditioned fear stimuli, for example, is still to be clarified. Although grooming behavior has been associated with some aspects of the obsessive-compulsive disorder in humans, its relation with other anxiety disorders is still unknown. Given that grooming behavior could be a component of the whole spectrum of these disorders, in the present study we allocated male Wistar rats in low, intermediate and high self-grooming groups according to the duration of such behavior in the elevated plus-maze (EPM). These groups were then evaluated in unconditioned fear tests, such as the EPM and the open-field, and in conditioned fear tests, such as fear-potentiated startle and fear extinction retention. Additionally, we studied the expression of unconditioned behaviors in marble burying test and the sensorimotor gate function with prepulse inhibition test. Neurochemicals and neuroendocrine parameters were also evaluated, with the quantification of basal corticosterone in the plasma, and dopamine, serotonin and their metabolites in brain structures involved with fear processing. In general, rats classified according to grooming expression showed similar performance in all behavioral tests. Accordingly, corticosterone and monoamine concentrations were similar among groups. Thus, despite grooming expression elicited by different approaches especially pharmacological ones has been related with some aspects of anxiety disorders, rats with different expression of spontaneous self-grooming in the EPM do not differ in anxiety-like behaviors nor in neurochemical and neuroendocrine parameters generally associated with anxiety disorders. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/09648-0 - Alterações do nível plasmático de BDNF e polimorfismos do gene de BDNF em pacientes com TOC submetidos ao paradigma de medo condicionado
• Beneficiário: Karina Soares de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/21357-9 - Investigação de circuitos neuronais e marcadores biológicos envolvidos no transtorno obsessivo-compulsivo por meio de paradigmas comportamentais de medo e ansiedade
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/04741-5 - Análise da mediação da e 5-HT do filtro sensório-motor e do processamento de informações condicionadas de medo em um modelo animal de transtorno obsessivo compulsivo
• Beneficiário: Adriano Edgar Reimer
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/00041-3 - Neurobiologia do estresse: a interface sensório-motora
• Beneficiário: Marcus Lira Brandão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/16864-4 - Capsulotomia ventral por raios gama com lesões únicas bilaterais e estimulação encefálica profunda no TOC: avaliação da eficácia, eventos adversos e alterações no funcionamento cerebral
• Beneficiário: Marcelo Queiroz Hoexter
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/00968-0 - Condicionamento, extinção e recuperação da resposta de medo em pacientes com transtorno obsessivo-compulsivo versus controles e após o tratamento com inibidores seletivos da recaptura de serotonina.
• Beneficiário: Juliana Belo Diniz
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado