| Texto completo | |
| Autor(es): |
Amorim, Jaime Henrique
[1]
;
dos Santos Alves, Rubens Prince
[1]
;
Bizerra, Raiza
[1]
;
Pereira, Sara Araujo
[1]
;
Pereira, Lennon Ramos
[1]
;
Nascimento Fabris, Denicar Lina
[1]
;
Santos, Robert Andreata
[1]
;
Romano, Camila Malta
[2, 3]
;
de Souza Ferreira, Luis Carlos
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Microbiol, Lab Desenvolvimento Vacinas, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Mol Infecciosas & Parasitarias LIMHC, Inst Med Trop Sao Paulo, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | VIROLOGY; v. 487, p. 41-49, JAN 2016. |
| Citações Web of Science: | 8 |
| Resumo | |
Generating neutralizing antibodies have been considered a prerequisite to control dengue virus (DENV) infection. However, T lymphocytes have also been shown to be important in a protective immune state. In order to investigate the contribution of both humoral and cellular immune responses in DENV immunity, we used an experimental model in which a non-lethal DENV2 strain (ACS46) is used to intracranially prime Balb/C mice which develop protective immunity against a lethal DENV2 strain (JHA1). Primed mice generated envelope-specific antibodies and CD8(+) T cell responses targeting mainly non-structural proteins. Immune sera from protected mice did not confer passive protection to naive mice challenged with the JHA1 strain. In contrast, depletion of CD4(+) and CD8(+) T lymphocytes significantly reduced survival of ACS46-primed mice challenged with the JHA1 strain. Collectively, results presented in this study show that a cellular immune response targeting non-structural proteins are a promising way in vaccine development against dengue. (C) 2015 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 12/51204-2 - Um novo caminho para a busca racional de uma vacina efetiva contra a dengue |
| Beneficiário: | Jaime Henrique Amorim Santos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |