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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population

Texto completo
Autor(es):
de Carvalho, Aline Martins [1, 2] ; Ferreira Carioca, Antonio Augusto [1] ; Fisberg, Regina Mara [1] ; Qi, Lu [2] ; Marchioni, Dirce Maria [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil
[2] Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: NUTRITION; v. 32, n. 2, p. 260-264, FEB 2016.
Citações Web of Science: 4
Resumo

Objective: To assess joint effects of heterocyclic amine (HCA), fruit, and vegetable intake on DNA damage in a general population. Methods: A cross-sectional survey (ISA-Capital) was performed among adults and older adults in Brazil. We selected 73 participants with high HCA intake and 73 sex- and age-matched participants with non-HCA intake (n = 146) for the present study. Diet was assessed by a 24-h dietary recall and a structured questionnaire with cooking methods and levels of meat doneness. DNA damage was measured by 8-oxo-2'-deoxyguanosine (8-OHdG). The association between DNA damage and dietary intake was analyzed by linear regression models. Results: Fruit intake showed significantly inverse association with 8-OHdG (beta, -0.787; P = 0.035), whereas HCA intake was significantly associated with increased DNA damage (beta, 1.621; P = 0.036) after adjusting for covariates, including sex, age, body mass index, energy intake, smoking, physical activity, and C-reactive protein. Vegetable intake was not significantly associated with 8-OHdG. We also found a significant association between joint fruit and HCA intake and DNA damage, and the difference in 8-OHdG levels was significantly higher between participants with the lowest fruit intake and highest HCA intake and those with the highest fruit intake and non-HCA intake (P = 0.049). Conclusions: Lower intake of fruits and higher intake of HCAs were associated with higher DNA damage levels and showed an additive effect pattern. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 14/04607-0 - Relação entre consumo de carne e aminas heterocíclicas e marcadores bioquímicos e genéticos
Beneficiário:Aline Martins de Carvalho
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
Beneficiário:Regina Mara Fisberg
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/10965-0 - Consumo de carnes e aminas heterocíclicas e sua relação com biomarcadores de exposição e suscetibilidade para câncer no estudo ISA-Capital
Beneficiário:Aline Martins de Carvalho
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/16347-2 - Assinatura metabólica em migrantes e sua relação com padrões de consumo e síndrome metabólica: uma abordagem epidemiológica para elucidar os efeitos da dieta
Beneficiário:Antonio Augusto Ferreira Carioca
Linha de fomento: Bolsas no Brasil - Doutorado