Joint association of fruit, vegetable, and heterocyclic amine intake with DNA damage levels in a general population

Autor(es)

de Carvalho, Aline Martins ^{[1, 2]} ; Ferreira Carioca, Antonio Augusto ^[1] ; Fisberg, Regina Mara ^[1] ; Qi, Lu ^[2] ; Marchioni, Dirce Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil

^[2] Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 - USA

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 32, n. 2, p. 260-264, FEB 2016.
• Citações Web of Science: 4

Resumo

Objective: To assess joint effects of heterocyclic amine (HCA), fruit, and vegetable intake on DNA damage in a general population. Methods: A cross-sectional survey (ISA-Capital) was performed among adults and older adults in Brazil. We selected 73 participants with high HCA intake and 73 sex- and age-matched participants with non-HCA intake (n = 146) for the present study. Diet was assessed by a 24-h dietary recall and a structured questionnaire with cooking methods and levels of meat doneness. DNA damage was measured by 8-oxo-2'-deoxyguanosine (8-OHdG). The association between DNA damage and dietary intake was analyzed by linear regression models. Results: Fruit intake showed significantly inverse association with 8-OHdG (beta, -0.787; P = 0.035), whereas HCA intake was significantly associated with increased DNA damage (beta, 1.621; P = 0.036) after adjusting for covariates, including sex, age, body mass index, energy intake, smoking, physical activity, and C-reactive protein. Vegetable intake was not significantly associated with 8-OHdG. We also found a significant association between joint fruit and HCA intake and DNA damage, and the difference in 8-OHdG levels was significantly higher between participants with the lowest fruit intake and highest HCA intake and those with the highest fruit intake and non-HCA intake (P = 0.049). Conclusions: Lower intake of fruits and higher intake of HCAs were associated with higher DNA damage levels and showed an additive effect pattern. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 14/04607-0 - Relação entre consumo de carne e aminas heterocíclicas e marcadores bioquímicos e genéticos
• Beneficiário: Aline Martins de Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/16347-2 - Assinatura metabólica em migrantes e sua relação com padrões de consumo e síndrome metabólica: uma abordagem epidemiológica para elucidar os efeitos da dieta
• Beneficiário: Antonio Augusto Ferreira Carioca
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/10965-0 - Consumo de carnes e aminas heterocíclicas e sua relação com biomarcadores de exposição e suscetibilidade para câncer no estudo ISA-Capital
• Beneficiário: Aline Martins de Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular