| Full text | |
| Author(s): |
de Carvalho, Aline Martins
[1, 2]
;
Ferreira Carioca, Antonio Augusto
[1]
;
Fisberg, Regina Mara
[1]
;
Qi, Lu
[2]
;
Marchioni, Dirce Maria
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil
[2] Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 - USA
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NUTRITION; v. 32, n. 2, p. 260-264, FEB 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
Objective: To assess joint effects of heterocyclic amine (HCA), fruit, and vegetable intake on DNA damage in a general population. Methods: A cross-sectional survey (ISA-Capital) was performed among adults and older adults in Brazil. We selected 73 participants with high HCA intake and 73 sex- and age-matched participants with non-HCA intake (n = 146) for the present study. Diet was assessed by a 24-h dietary recall and a structured questionnaire with cooking methods and levels of meat doneness. DNA damage was measured by 8-oxo-2'-deoxyguanosine (8-OHdG). The association between DNA damage and dietary intake was analyzed by linear regression models. Results: Fruit intake showed significantly inverse association with 8-OHdG (beta, -0.787; P = 0.035), whereas HCA intake was significantly associated with increased DNA damage (beta, 1.621; P = 0.036) after adjusting for covariates, including sex, age, body mass index, energy intake, smoking, physical activity, and C-reactive protein. Vegetable intake was not significantly associated with 8-OHdG. We also found a significant association between joint fruit and HCA intake and DNA damage, and the difference in 8-OHdG levels was significantly higher between participants with the lowest fruit intake and highest HCA intake and those with the highest fruit intake and non-HCA intake (P = 0.049). Conclusions: Lower intake of fruits and higher intake of HCAs were associated with higher DNA damage levels and showed an additive effect pattern. (C) 2016 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 14/04607-0 - Relationship between meat and heterocyclic amines intake and biochemical and genetic biomarkers |
| Grantee: | Aline Martins de Carvalho |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 14/16347-2 - Metabolic signature on migrants and their relationship to patterns of consumption and metabolic syndrome: an epidemiological approach to elucidate the effects of diet |
| Grantee: | Antonio Augusto Ferreira Carioca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/10965-0 - Meat and heterocyclic amines intake, relationship with biomarkers for exposure and susceptibility to cancer in ISA-Capital study |
| Grantee: | Aline Martins de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 09/15831-0 - Dietary factors, homocystein, MTHFR gene polymorphisms, and cardiovascular risk in adults and the elderly: a population-based study - ISA - Capital |
| Grantee: | Regina Mara Fisberg |
| Support Opportunities: | Regular Research Grants |