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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring

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Autor(es):
Payolla, Tanyara Baliani [1] ; Lemes, Simone Ferreira [2] ; de Fante, Thais [1] ; Reginato, Andressa [1] ; da Silva, Cristiano Mendes [3, 4] ; Micheletti, Thayana de Oliveira [1] ; Rodrigues, Hosana Gomes [1] ; Torsoni, Adriana Souza [3, 1, 4] ; Milanski, Marciane [3, 1, 4] ; Torsoni, Marcio Alberto [3, 1, 4]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Appl Sci, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Molecular and Cellular Endocrinology; v. 422, n. C, p. 192-202, FEB 15 2016.
Citações Web of Science: 8
Resumo

Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-alpha was elevated in the HFD-O mice. STAT3 and NF-kappa B activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-alpha and IL-1 beta expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP. (C) 2015 Published by Elsevier Ireland Ltd. (AU)

Processo FAPESP: 13/10706-8 - Modulação da via anti-inflamatória colinérgica no fígado da prole pelo consumo materno de dieta rica em gordura.
Beneficiário:Tanyara Baliani Payolla
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/18165-9 - Consumo materno de dieta hiperlipídica e a modulação da via anti-inflamatória colinérgica na prole de camundongos
Beneficiário:Marcio Alberto Torsoni
Linha de fomento: Auxílio à Pesquisa - Regular