Insulin signaling evaluation and the effects of activation of antiinflammatory cho...
| Full text | |
| Author(s): |
Payolla, Tanyara Baliani
[1]
;
Lemes, Simone Ferreira
[2]
;
de Fante, Thais
[1]
;
Reginato, Andressa
[1]
;
da Silva, Cristiano Mendes
[3, 4]
;
Micheletti, Thayana de Oliveira
[1]
;
Rodrigues, Hosana Gomes
[1]
;
Torsoni, Adriana Souza
[3, 1, 4]
;
Milanski, Marciane
[3, 1, 4]
;
Torsoni, Marcio Alberto
[3, 1, 4]
Total Authors: 10
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Appl Sci, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Molecular and Cellular Endocrinology; v. 422, n. C, p. 192-202, FEB 15 2016. |
| Web of Science Citations: | 8 |
| Abstract | |
Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-alpha was elevated in the HFD-O mice. STAT3 and NF-kappa B activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-alpha and IL-1 beta expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP. (C) 2015 Published by Elsevier Ireland Ltd. (AU) | |
| FAPESP's process: | 14/18165-9 - Maternal consumption of high fat diet and modulation of cholinergic anti-inflammatory pathway in offspring of mice |
| Grantee: | Marcio Alberto Torsoni |
| Support type: | Regular Research Grants |
| FAPESP's process: | 13/10706-8 - Modulation of anti-inflammatory cholinergic pathway in the liver of the offspring by maternal consumption of high-fat diet |
| Grantee: | Tanyara Baliani Payolla |
| Support type: | Scholarships in Brazil - Master |