An Overview of B-1 Cells as Antigen-Presenting Cells

Autor(es)

Popi, Ana F. ^[1] ; Longo-Maugeri, Ieda M. ^[1] ; Mariano, Mario ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 7, APR 11 2016.
• Citações Web of Science: 16

Resumo

The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response. (AU)

• Processo FAPESP: 08/58561-0 - Células B-1 na embriologia, diferenciação e imunomodulação
• Beneficiário: Mario Mariano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/01986-2 - Ikaros: papel na sinalização via BCR de células B-1 e correlação com leucemia linfocítica crônica
• Beneficiário: Ana Flavia Popi
• Modalidade de apoio: Auxílio à Pesquisa - Regular