An Overview of B-1 Cells as Antigen-Presenting Cells

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Author(s):	Popi, Ana F. ^[1] ; Longo-Maugeri, Ieda M. ^[1] ; Mariano, Mario ^[1] Total Authors: 3
Affiliation:	^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo - Brazil Total Affiliations: 1
Document type:	Review article
Source:	FRONTIERS IN IMMUNOLOGY; v. 7, APR 11 2016.
Web of Science Citations:	16
Abstract
The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response. (AU)

FAPESP's process:	15/01986-2 - Ikaros: role in the BCR- signaling in B-1 cells and association with chronic lymphocytic leukemia
Grantee:	Ana Flavia Popi
Support Opportunities:	Regular Research Grants