| Texto completo | |
| Autor(es): |
Sanches Silveira, Loreana
;
Mello Antunes, Barbara de Moura
;
Araujo Minari, Andre Luis
;
Thomatieli dos Santos, Ronaldo Vagner
;
Rosa Neto, Jose Cesar
;
Lira, Fabio Santos
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION; v. 26, n. 2, p. 115-132, 2016. |
| Citações Web of Science: | 4 |
| Resumo | |
Macrophages are cells of the innate immune response that trigger inflammation resolution. The phenotype of ``classically activated macrophages{''} (M1) has anti-tumoricidal and anti-bactericidal activities. On the other hand, ``alternatively activated macrophages{''} (M2) are involved in tissue remodeling and immunomodulatory functions. The change in the polarization of macrophages varies according to the diversity of cytokines present in the microenvironment or by the stimuli of an antigen. It involves such factors as interferon-regulatory factors, peroxisome proliferator-activated receptors (PPARs), hypoxia-inducible factors (HIFs), and signal transducers and activators of transcription (STATs). Switching the phenotype of macrophages can help attenuate the development of an inflammatory disease. Exercise can promote alterations in the number of innate immune cells and stimulates phagocytic function. Chronic exercise seems to inhibit macrophage infiltration into adipose tissue by attenuating the expression of F4/80 mRNA. Furthermore, exercise may also increase the expression of M2 markers and reduce TNF-alpha and TLR4 mRNA expression, which activates the inflammatory pathway of NF-kappa B. Chronic exercise reduces beta 2-adrenergic receptors in monocytes and macrophages by modulating TLR4 signaling as well as suppressing IL-12 production, a stimulator of interferon.. In this review, we discuss macrophage polarization in metabolic diseases and how exercise can modulate macrophage plasticity. (AU) | |
| Processo FAPESP: | 14/08003-1 - Envolvimento do NF-kB e PPAR-gamma na resposta inflamatória e metabólica em monócitos de indivíduos sedentários, fisicamente ativos e treinados |
| Beneficiário: | Barbara de Moura Mello Antunes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/25310-2 - Avaliação da resposta imuno-metabólica em células sanguíneas em indivíduos obesos: papel do exercício físico e do PPAR-gama |
| Beneficiário: | Fábio Santos de Lira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/09367-4 - Efeitos metabólicos da doxorrubicina no músculo esquelético e tecido adiposo: possível papel adjuvante do treinamento físico e metformina |
| Beneficiário: | José Cesar Rosa Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/01246-6 - Avaliação da resposta imuno-metabólica em macrófagos peritoneais de camundongos obesos: papel do exercício físico e do PPAR-gamma |
| Beneficiário: | Loreana Sanches Silveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |