The microbiota and chronic kidney diseases: a double-edged sword

Autor(es)

Ferreira Felizardo, Raphael Jose ; Castoldi, Angela ; Andrade-Oliveira, Vinicius ; Saraiva Camara, Niels Olsen

• Tipo de documento: Artigo de Revisão
• Fonte: CLINICAL & TRANSLATIONAL IMMUNOLOGY; v. 5, JUN 2016.
• Citações Web of Science: 18

Resumo

Recent findings regarding the influence of the microbiota in many inflammatory processes have provided a new way to treat diseases. Now, one may hypothesize that the origin of a plethora of diseases is related to the health of the gut microbiota and its delicate, although complex, interface with the epithelial and immune systems. The `westernization' of diets, for example, is associated with alterations in the gut microbiota. Such alterations have been found to correlate directly with the increased incidence of diabetes and hypertension, the main causes of chronic kidney diseases (CKDs), which, in turn, have a high estimated prevalence. Indeed, data have arisen showing that the progression of kidney diseases is strictly related to the composition of the microbiota. Alterations in the gut microbiota diversity during CKDs do not only have the potential to exacerbate renal injury but may also contribute to the development of associated comorbidities, such as cardiovascular diseases and insulin resistance. In this review, we discuss how dysbiosis through alterations in the gut barrier and the consequent activation of immune system could intensify the progression of CKD and vice versa, how CKDs can modify the gut microbiota diversity and abundance. (AU)

• Processo FAPESP: 12/15205-4 - Papel dos ácidos graxos de cadeia curta na glomeruloesclerose segmentar e focal experimental
• Beneficiário: Raphael Jose Ferreira Felizardo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/18121-4 - Estudo da relação entre a obesidade e a função das células da lâmina própria intestinal no desenvolvimento da resistência à insulina
• Beneficiário: Angela Castoldi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado