Punicalagin promotes human villous trophoblast differentiation

Autor(es)

Chen, Baosheng ; Longtine, Mark S. ; Costa, Maria Laura ; Nelson, D. Michael

• Tipo de documento: Artigo Científico
• Fonte: Placenta; v. 44, p. 80-82, AUG 2016.
• Citações Web of Science: 2

Resumo

Poor differentiation of trophoblasts is associated with placental dysfunction, predisposing women to multiple pregnancy disorders. Punicalagin, a prominent ellagitannin in pomegranate juice has been shown to exert anti-apoptosis and anti-oxidative effects in human trophoblasts. We hypothesized that punicalagin modulates trophoblast differentiation. We found that punicalagin-treated primary trophoblast showed reduced E-cadherin, higher Syncytin 1, more beta-hCG, and increased GCM1, an upstream regulator of beta-hCG. Punicalagin exposure of villous explants enhanced the number of cytotrophoblasts expressing the proliferation marker Ki67. We conclude that punicalagin enhances trophoblast differentiation and speculate that punicalagin might be used therapeutically in pregnancies at risk for placental dysfunction. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 14/01925-0 - Atividade biológica de células apresentadoras de antígeno em gestações normais e com pré-eclâmpsia
• Beneficiário: Maria Laura Costa do Nascimento
• Modalidade de apoio: Bolsas no Exterior - Pesquisa