Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

Autor(es)

Andre, Greiciely O. ; Converso, Thiago R. ; Politano, Walter R. ; Ferraz, Lucio F. C. ; Ribeiro, Marcelo L. ; Leite, Luciana C. C. ; Darrieux, Michelle

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN MICROBIOLOGY; v. 8, FEB 20 2017.
• Citações Web of Science: 16

Resumo

The complement system plays a central role in immune defense against Streptococcus pneumoniae. In order to evade complement attack, pneumococci have evolved a number of mechanisms that limit complement mediated opsonization and subsequent phagocytosis. This review focuses on the strategies employed by pneumococci to circumvent complement mediated immunity, both in vitro and in vivo. At last, since many of the proteins involved in interactions with complement components are vaccine candidates in different stages of validation, we explore the use of these antigens alone or in combination, as potential vaccine approaches that aim at elimination or drastic reduction in the ability of this bacterium to evade complement. (AU)

• Processo FAPESP: 14/01115-9 - Análise da resposta celular induzida no pulmão pela imunização de camundongos com vacinas pneumocócicas híbridas PspA-Ply
• Beneficiário: Michelle Darrieux Sampaio Bertoncini
• Modalidade de apoio: Auxílio à Pesquisa - Regular