| Texto completo | |
| Autor(es): |
Oliveira, V.
;
Silva Junior, S. D.
;
de Carvalho, M. H. C.
;
Akamine, E. H.
;
Michelini, L. C.
;
Franco, M. C.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 8, n. 2, p. 236-243, APR 2017. |
| Citações Web of Science: | 1 |
| Resumo | |
It has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-alpha expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors. Pregnant Wistar rats received ad libitum or 50% of ad libitum diet throughout gestation. At 8 weeks of age, male offspring from both groups were randomly assigned to control, trained control, restricted and trained restricted. Aerobic training protocol was performed on a treadmill and after that, we evaluated circulating mtDNA, cardiac protein expression of TLR9, plasma and cardiac TNF-levels, and left ventricle (LV) mass. We found that IUGR promoted an increase in the circulating mtDNA, TLR9 expression and plasma TNF-alpha levels. Further, our results revealed that aerobic training can restore mtDNA/TLR9 content and plasma levels of TNF-alpha among restricted rats. The cardiac TNF-alpha content and LV mass were not influenced either by IUGR or aerobic training. In conclusion, IUGR can program mtDNA/TLR9 content, which may lead to high levels of TNF-alpha. However, aerobic training was able to normalize these alterations. These findings evidenced that the association of IUGR and aerobic training seems to exert an important interaction effect regarding pro-inflammatory condition and, aerobic training may be used as a strategy to reduce deleterious adaptations in IUGR offspring. (AU) | |
| Processo FAPESP: | 13/00311-6 - Isolamento e caracterização de células progenitoras endoteliais circulantes e de medula óssea de ratos submetidos à restrição de nutrientes in útero: avaliação do impacto do treinamento físico aeróbio e do balanço redox |
| Beneficiário: | Vanessa Aparecida de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/03139-0 - Inter-relação do peso ao nascer, treinamento físico e níveis pressóricos: uma abordagem clínica e experimental sobre o papel das células progenitoras endoteliais |
| Beneficiário: | Maria Do Carmo Pinho Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |