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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: could aerobic training counteract these adaptations?

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Oliveira, V. ; Silva Junior, S. D. ; de Carvalho, M. H. C. ; Akamine, E. H. ; Michelini, L. C. ; Franco, M. C.
Total Authors: 6
Document type: Journal article
Web of Science Citations: 1

It has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-alpha expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors. Pregnant Wistar rats received ad libitum or 50% of ad libitum diet throughout gestation. At 8 weeks of age, male offspring from both groups were randomly assigned to control, trained control, restricted and trained restricted. Aerobic training protocol was performed on a treadmill and after that, we evaluated circulating mtDNA, cardiac protein expression of TLR9, plasma and cardiac TNF-levels, and left ventricle (LV) mass. We found that IUGR promoted an increase in the circulating mtDNA, TLR9 expression and plasma TNF-alpha levels. Further, our results revealed that aerobic training can restore mtDNA/TLR9 content and plasma levels of TNF-alpha among restricted rats. The cardiac TNF-alpha content and LV mass were not influenced either by IUGR or aerobic training. In conclusion, IUGR can program mtDNA/TLR9 content, which may lead to high levels of TNF-alpha. However, aerobic training was able to normalize these alterations. These findings evidenced that the association of IUGR and aerobic training seems to exert an important interaction effect regarding pro-inflammatory condition and, aerobic training may be used as a strategy to reduce deleterious adaptations in IUGR offspring. (AU)

FAPESP's process: 13/00311-6 - Isolation and characterization of bone marrow and circulating progenitor endothelial cells of rats submitted to intrauterine undernutrition: impact of aerobic training and oxidative stress
Grantee:Vanessa Aparecida de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/03139-0 - The interrelationship of birth weight, physical training and blood pressure levels: a clinical and experimental approach on the role of endothelial progenitor cells
Grantee:Maria Do Carmo Pinho Franco
Support type: Regular Research Grants