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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Dorsal striatum D1-expressing neurons are involved with sensorimotor gating on prepulse inhibition test

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Autor(es):
Rodrigues, Samanta ; Salum, Cristiane ; Ferreira, Tatiana L.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PSYCHOPHARMACOLOGY; v. 31, n. 4, p. 505-513, APR 2017.
Citações Web of Science: 6
Resumo

Prepulse inhibition (PPI) is a behavioral test in which the startle reflex response to a high-intensity stimulus (pulse) is inhibited by the prior presentation of a weak stimulus (prepulse). The classic neural circuitry that mediates startle response is localized in the brainstem; however, recent studies point to the contribution of structures involved in higher cognitive functions in regulating the sensorimotor gating, particularly forebrain regions innervated by dopaminergic nuclei. The aim of the present study was to verify the role of dorsal striatum (DS) and dopaminergic transmitting mediated by D1 and D2 receptors on PPI test in rats. DS inactivation induced by muscimol injection did not affect PPI (%PPI and startle response), although it impaired the locomotor activity and caused catalepsy. Infusion of D1-like antagonist SCH23390 impaired %PPI but did not disturb the startle response and locomotor activity evaluated immediately after PPI test. D2 antagonist microinjection (sulpiride) did not affect %PPI and startle response, but impaired motor activity. These results point to an important role of DS, probably mediated by direct basal ganglia pathway, on modulation of sensorimotor gating, in accordance with clinical studies showing PPI deficits in schizophrenia, Tourette syndrome, and compulsive disorders - pathologies related to basal ganglia dysfunctions. (AU)

Processo FAPESP: 11/09548-3 - Avaliação dos efeitos de inibidores da sintase de óxido nítrico em modelos animais para o estudo da esquizofrenia baseados nas hipóteses farmacológicas e do neurodesenvolvimento
Beneficiário:Cristiane Otero Reis Salum
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/17024-4 - Papel do estriado dorsal sobre a memória emocional e atenção, avaliado pela resposta de sobressalto
Beneficiário:Samanta Rodrigues
Modalidade de apoio: Bolsas no Brasil - Mestrado