Therapeutic effect of monophosphoryl lipid A administration on Paracoccidioides brasiliensis-infected mice

Autor(es)

Landgraf, Taise Natali ; Fernandes, Fabricio Freitas ; Peron, Gabriela ; Panunto-Castelo, Ademilson

• Tipo de documento: Artigo Científico
• Fonte: Medical Mycology; v. 55, n. 3, p. 344-348, APR 2017.
• Citações Web of Science: 1

Resumo

The lack of antifungals with low toxicity and short-term therapy for patients with paracoccidioidomycosis (PCM) led us to evaluate adjuvants in immunotherapeutic intervention. We have previously shown complete Freund's adjuvant (CFA) to be therapeutic on experimental PCM. Owing to CFA toxicity, here we tested adjuvants approved for clinical use or in preclinical phase in experimental mouse PCM. Of all, only monophosporyl lipid A (MPLA) demonstrates a beneficial effect, by reducing the fungal burden and increasing the concentrations of IFN-gamma and TNF-alpha, which are immunoprotective in PCM. These results suggest that MPLA might improve intervention in PCM. (AU)

• Processo FAPESP: 13/12278-3 - Rastreamento de antígenos de Paracoccidioides brasiliensis com potencial imunoterapêutico na paracoccidioidomicose
• Beneficiário: Ademilson Panunto-Castelo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/08552-0 - Identificação de antígenos de Paracoccidioides brasiliensis com potencial imunoterapêutico para o tratamento de paracoccidioidomicose.
• Beneficiário: Taise Natali Landgraf
• Modalidade de apoio: Bolsas no Brasil - Doutorado