Therapeutic effect of monophosphoryl lipid A administration on Paracoccidioides brasiliensis-infected mice

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Author(s):	Landgraf, Taise Natali ; Fernandes, Fabricio Freitas ; Peron, Gabriela ; Panunto-Castelo, Ademilson Total Authors: 4
Document type:	Journal article
Source:	Medical Mycology; v. 55, n. 3, p. 344-348, APR 2017.
Web of Science Citations:	1
Abstract
The lack of antifungals with low toxicity and short-term therapy for patients with paracoccidioidomycosis (PCM) led us to evaluate adjuvants in immunotherapeutic intervention. We have previously shown complete Freund's adjuvant (CFA) to be therapeutic on experimental PCM. Owing to CFA toxicity, here we tested adjuvants approved for clinical use or in preclinical phase in experimental mouse PCM. Of all, only monophosporyl lipid A (MPLA) demonstrates a beneficial effect, by reducing the fungal burden and increasing the concentrations of IFN-gamma and TNF-alpha, which are immunoprotective in PCM. These results suggest that MPLA might improve intervention in PCM. (AU)

FAPESP's process:	13/12278-3 - Screening of Paracoccidioides brasiliensis antigens with potential immunotherapeutic application in paracoccidioidomicose
Grantee:	Ademilson Panunto-Castelo
Support Opportunities:	Regular Research Grants


FAPESP's process:	12/08552-0 - Identification of antigens from Paracoccidioides brasiliensis with immunotherapeutic potential for the treatment of paracoccidioidomycosis.
Grantee:	Taise Natali Landgraf
Support Opportunities:	Scholarships in Brazil - Doctorate