Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury

Autor(es)

Tajra Feitosa, Matheus Levi ; Palmeira Sarmento, Carlos Alberto ; Bocabello, Renato Zonzini ; Baleeiro Beltrao-Braga, Patricia Cristina ; Pignatari, Graciela Conceicao ; Giglio, Robson Fortes ; Miglino, Maria Angelica ; Orlandin, Jessica Rodrigues ; Ambrosio, Carlos Eduardo

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 32, n. 7, p. 540-549, JUL 2017.
• Citações Web of Science: 8

Resumo

Abstract Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy. (AU)

• Processo FAPESP: 09/51605-4 - Terapia celular em coelhos com lesao medular induzida (modelo de rastreamento e eficiencia) em caes com lesao medular compressiva causada por hernia toracolombar de disco.
• Beneficiário: Matheus Levi Tajra Feitosa
• Modalidade de apoio: Bolsas no Brasil - Doutorado