Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury

Tajra Feitosa, Matheus Levi; Palmeira Sarmento, Carlos Alberto; Bocabello, Renato Zonzini; Baleeiro Beltrao-Braga, Patricia Cristina; Pignatari, Graciela Conceicao; Giglio, Robson Fortes; Miglino, Maria Angelica; Orlandin, Jessica Rodrigues; Ambrosio, Carlos Eduardo

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transplantation of human immature dental pulp stem cell in dogs with chronic spinal cord injury

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Author(s):	Tajra Feitosa, Matheus Levi ; Palmeira Sarmento, Carlos Alberto ; Bocabello, Renato Zonzini ; Baleeiro Beltrao-Braga, Patricia Cristina ; Pignatari, Graciela Conceicao ; Giglio, Robson Fortes ; Miglino, Maria Angelica ; Orlandin, Jessica Rodrigues ; Ambrosio, Carlos Eduardo Total Authors: 9
Document type:	Journal article
Source:	Acta Cirurgica Brasileira; v. 32, n. 7, p. 540-549, JUL 2017.
Web of Science Citations:	8
Abstract
Abstract Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation. Conclusion: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy. (AU)

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