Bj-PRO-5a and Bj-PRO 10c Found at C-Type Natriuretic Peptide Precursor of Bothrops jararaca Change Renal Function of Hypertensive Rats

Autor(es)

Xavier, Carlos H. ; Miranda, Jose Rodolfo R. ; Yamaguchi, Juliana ; da Silveira, Katia D. ; Teixeira, Mauro M. ; Chianca-, Jr., Deoclecio Alves ; Simoes e Silva, Ana C. ; Santos, Robson A. S. ; Camargo, Antonio C. M. ; Ianzer, Danielle

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS; v. 23, n. 3, p. 381-385, SEP 2017.
• Citações Web of Science: 1

Resumo

Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1-43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj-PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Delta = -13 to -24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal function of SHRs through diuretic and natriuretic mechanisms. (AU)

• Processo FAPESP: 98/14307-9 - Center for Applied Toxinology
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 08/54820-0 - Avaliacao dos efeitos dos bpps sobre os parametros da funcao renal em ratos espontaneamente hipertensos.
• Beneficiário: Danielle Alves Ianzer
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado