| Full text | |
| Author(s): |
Xavier, Carlos H.
;
Miranda, Jose Rodolfo R.
;
Yamaguchi, Juliana
;
da Silveira, Katia D.
;
Teixeira, Mauro M.
;
Chianca-, Jr., Deoclecio Alves
;
Simoes e Silva, Ana C.
;
Santos, Robson A. S.
;
Camargo, Antonio C. M.
;
Ianzer, Danielle
Total Authors: 10
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS; v. 23, n. 3, p. 381-385, SEP 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1-43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj-PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Delta = -13 to -24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal function of SHRs through diuretic and natriuretic mechanisms. (AU) | |
| FAPESP's process: | 98/14307-9 - Center for Applied Toxinology |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |