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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Arterial stiffness and its association with clustering of metabolic syndrome risk factors

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Autor(es):
Lopes-Vicente, Wanda R. P. [1] ; Rodrigues, Sara [2] ; Cepeda, Felipe X. [2] ; Jordao, Camila Paixao [2] ; Costa-Hong, Valeria [2] ; Dutra-Marques, Akothirene C. B. [2] ; Carvalho, Jefferson C. [2] ; Alves, Maria Janieire N. N. [2] ; Bortolotto, Luiz A. [2] ; Trombetta, Ivani C. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Nove de Julho UNINOVE, Programa Pos Grad Med, Rua Vergueiro 235-249, BR-01504001 Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Hosp Clin, Fac Med, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: DIABETOLOGY & METABOLIC SYNDROME; v. 9, OCT 25 2017.
Citações Web of Science: 8
Resumo

Background: Metabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients. Methods: Recently diagnosed and untreated patients with MetS (n = 64, 49 +/- 8 year, 32 +/- 4 kg/m(2)) were selected, according to ATP III criteria and compared to a control group (Control, n = 17, 49 +/- 6 year, 27 +/- 2 kg/m(2)). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations. Results: Patients with MetS had increased PWV when compared to Control (7.8 +/- 1.1 vs. 7.0 +/- 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (beta = 0.450, p < 0.001), systolic blood pressure (beta = 0.211, p = 0.023) and triglycerides (beta = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 +/- 0.4 vs. 7.5 +/- 0.2, p = 0.011 and 7.2 +/- 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 +/- 0.2 vs. 7.2 +/- 0.3, p = 0.047). Conclusions: The number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients. (AU)

Processo FAPESP: 16/16831-7 - Marcadores metabólicos/inflamatórios e balanço simpato-vagal em pacientes com síndrome metabólica e apneia obstrutiva do sono: efeito da dieta hipocalórica e treinamento físico
Beneficiário:Felipe Xerez Cepêda Fonseca
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 11/17533-6 - Aspectos autonômicos, metabólicos e inflamatórios da associação da síndrome metabólica com a apnéia obstrutiva do sono: efeito da dieta hipocalórica e do treinamento físico
Beneficiário:Ivani Credidio Trombetta
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/15323-0 - Rigidez arterial e resistência vascular periférica na síndrome metabólica : efeito da dieta hipocalórica associada ao treinamento físico
Beneficiário:Sara Rodrigues
Linha de fomento: Bolsas no Brasil - Mestrado