Liposomal formulations in the pharmacological treatment of leishmaniasis: a review

Autor(es)

Ortega, Vanessa ^{[1, 2]} ; Giorgio, Selma ^[1] ; de Paula, Eneida ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Anim Biol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, POB 6109, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Liposome Research; v. 27, n. 3, p. 234-248, 2017.
• Citações Web of Science: 2

Resumo

Conventional chemotherapy for leishmaniasis includes considerably toxic drugs and reports of drug-resistance are not uncommon. Liposomal encapsulated drugs appear as an option for the treatment of leishmaniasis, providing greater efficacy for the active and reducing its side effects by promoting superior tissue absorption, favouring drug penetration into the macrophages, and retarding its clearance from the site of action. In this paper, a review on the advances achieved with liposome-based anti-leishmaniasis drug delivery systems is presented. Formulations prepared with either conventional or modified (sugar-coated, cationic, niosomes, peptides- and antibodies-bounded) liposomes for the delivery of pentavalent antimonials, amphotericin B, pentamidine, paromomycyn, and miltefosine were covered. This literature review depicts a scenario of no effective therapeutic agents for the treatment of this neglected disease, where liposomal formulations appear to improve the effectiveness of the available antileishmania agents. (AU)

• Processo FAPESP: 14/12443-7 - Desenvolvimento de sistema de duplo carregamento para o antimoniato de meglumina e sua avaliação in vitro em macrófagos infectados com L. infantum
• Beneficiário: Vicky Vanessa Ortega Gaona
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/01536-1 - Interações Leishmania amazonensis-macrófago: mudanças homeostáticas associadas a super-expressão de HSP70. Perfil celular de lesões leishmanióticas: efeitos de inibidores de Gliceraldeído 3-fosfato desidrogenase
• Beneficiário: Selma Giorgio
• Modalidade de apoio: Auxílio à Pesquisa - Regular