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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Liposomal formulations in the pharmacological treatment of leishmaniasis: a review

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Author(s):
Ortega, Vanessa [1, 2] ; Giorgio, Selma [1] ; de Paula, Eneida [2]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Anim Biol, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, POB 6109, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Liposome Research; v. 27, n. 3, p. 234-248, 2017.
Web of Science Citations: 2
Abstract

Conventional chemotherapy for leishmaniasis includes considerably toxic drugs and reports of drug-resistance are not uncommon. Liposomal encapsulated drugs appear as an option for the treatment of leishmaniasis, providing greater efficacy for the active and reducing its side effects by promoting superior tissue absorption, favouring drug penetration into the macrophages, and retarding its clearance from the site of action. In this paper, a review on the advances achieved with liposome-based anti-leishmaniasis drug delivery systems is presented. Formulations prepared with either conventional or modified (sugar-coated, cationic, niosomes, peptides- and antibodies-bounded) liposomes for the delivery of pentavalent antimonials, amphotericin B, pentamidine, paromomycyn, and miltefosine were covered. This literature review depicts a scenario of no effective therapeutic agents for the treatment of this neglected disease, where liposomal formulations appear to improve the effectiveness of the available antileishmania agents. (AU)

FAPESP's process: 14/12443-7 - Development of a double loading system for meglumine antimoniate and its in vitro evaluation in macrophages infected with L. infantum
Grantee:Vicky Vanessa Ortega Gaona
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/01536-1 - Leishmania amazonensis-macrophage interactions: homeostatic changes associated with HSP70 overexpression in L. amazonensis cellular profile of leishmaniasis lesions effects of glyceraldehyde 3-phosphate dehydrogenase inhibitors
Grantee:Selma Giorgio
Support Opportunities: Regular Research Grants