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Development of a double loading system for meglumine antimoniate and its in vitro evaluation in macrophages infected with L. infantum

Grant number: 14/12443-7
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2014
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Eneida de Paula
Grantee:Vicky Vanessa Ortega Gaona
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Leishmaniosis refers to a complex of infectious illnesses caused by intramacrophage Leishmania that can be fatal if not properly treated. Visceral leishmaniosis is a neglected disease, related to poverty and considered by the World Health Organization as the sixth more relevant endemic disease in the world. In Brazil it is a zoonosis that has dogs as the main urban reservatory of the parasite, and its control includes euthanasia of serum positive animals. Just a few medicines are available for the treatment of Canine Visceral Leishmaniosis (CVL), and they present limitations related to toxicity, efficacy, price and therapeutic schemes. In this project we intend to develop and to characterize a new drug delivery system for Meglumine Antimoniate (AME) in double-loaded liposomes, i.e., that contains AME complexed in Hydropropyl-Beta-Cyclodextrin for the in vitro treatment of CVL. We also intend to evaluate the mechanisms involved in the internalization, intracellular traffic and co-location of liposomes and parasites inside DH82 canine macrophage cells. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ORTEGA, VANESSA; GIORGIO, SELMA; DE PAULA, ENEIDA. Liposomal formulations in the pharmacological treatment of leishmaniasis: a review. Journal of Liposome Research, v. 27, n. 3, p. 234-248, 2017. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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