Biological network border detection

Autor(es)

Burke, Paulo E. P. ^[1] ; Comin, Cesar H. ^[2] ; Silva, Filipi N. ^[3] ; Costa, Luciano da F. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bioinformat Grad Program, Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Comp Sci, Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTEGRATIVE BIOLOGY; v. 9, n. 12, p. 947-955, DEC 2017.
• Citações Web of Science: 1

Resumo

Complex networks have been widely used to model biological systems. The concept of accessibility has been proposed recently as a means to organize the nodes of complex networks as belonging to its border or center. Such an approach paves the way to investigating how the functional and structural properties of nodes vary with their respective position in the networks. In this work, we approach such a problem in a biological context applying border detection to Protein-Protein Interaction networks from four organisms of the Mycoplasma genus. We found evidence that the borderness of proteins bears a relation with their spatial organization and molecular function specificity. (AU)

• Processo FAPESP: 15/18942-8 - Associando Redes Complexas com Espaços Efetivos de Atributos
• Beneficiário: Cesar Henrique Comin
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/50761-2 - Modelos e métodos de e-Science para ciências da vida e agrárias
• Beneficiário: Roberto Marcondes Cesar Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/08003-4 - Abordagem de redes complexas em e-Science e dados dinâmicos
• Beneficiário: Filipi Nascimento Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado