| Texto completo | |
| Autor(es): |
Correa, Renan Oliveira
[1]
;
Fachi, Jose Luis
[1]
;
Vieira, Aline
[1]
;
Sato, Fabio Takeo
[1]
;
Vinolo, Marco Aurelio R.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, BR-13083862 Campinas, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | CLINICAL & TRANSLATIONAL IMMUNOLOGY; v. 5, APR 2016. |
| Citações Web of Science: | 159 |
| Resumo | |
Short-chain fatty acids (SCFAs) are bacterial fermentation products, which are chemically composed by a carboxylic acid moiety and a small hydrocarbon chain. Among them, acetic, propionic and butyric acids are the most studied, presenting, respectively, two, three and four carbons in their chemical structure. These metabolites are found in high concentrations in the intestinal tract, from where they are uptaken by intestinal epithelial cells (IECs). The SCFAs are partially used as a source of ATP by these cells. In addition, these molecules act as a link between the microbiota and the immune system by modulating different aspects of IECs and leukocytes development, survival and function through activation of G protein coupled receptors (FFAR2, FFAR3, GPR109a and Olfr78) and by modulation of the activity of enzymes and transcription factors including the histone acetyltransferase and deacetylase and the hypoxia-inducible factor. Considering that, it is not a surprise, the fact that these molecules and/or their targets are suggested to have an important role in the maintenance of intestinal homeostasis and that changes in components of this system are associated with pathological conditions including inflammatory bowel disease, obesity and others. The aim of this review is to present a clear and updated description of the effects of the SCFAs derived from bacteria on host immune system, as well as the molecular mechanisms involved on them. (AU) | |
| Processo FAPESP: | 12/15774-9 - Aplicação de inibidores de histonas desacetilase no tratamento da obesidade e resistência à insulina associada |
| Beneficiário: | Fabio Takeo Sato |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/02560-6 - Participação dos ácidos graxos de cadeia curta e seu receptor (GPR43) na resposta imune em modelo de monoinfecção por Aggregatibacter actinomycetemcomitans |
| Beneficiário: | Renan Oliveira Corrêa |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 12/10653-9 - Envolvimento dos ácidos graxos de cadeia curta e seu receptor (GPR43) na resposta imune a bactérias anaeróbias in vivo e in vitro |
| Beneficiário: | Marco Aurélio Ramirez Vinolo |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |