Autor(es)

Salgueiro Barboni, Mirella Telles ^{[1, 2]} ; Bueno, Clarissa ^[3] ; Nagy, Balazs Vince ^{[1, 4]} ; Maia, Patricia Lobo ^[3] ; Moreira Vidal, Kallene Summer ^[1] ; Alves, Rosana Cardoso ^[3] ; Reiter, Russel J. ^[5] ; do Amaral, Fernanda Gaspar ^[6] ; Cipolla-Neto, Jose ^[7] ; Ventura, Dora Fix ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Expt Psychol, Inst Psychol, Sao Paulo - Brazil

^[2] Semmelweis Univ, Dept Ophthalmol, Budapest - Hungary

^[3] Univ Sao Paulo, Dept Neurol, Fac Med, Sao Paulo - Brazil

^[4] Budapest Univ Technol & Econ, Dept Mechatron Opt & Engn Informat, Budapest - Hungary

^[5] Univ Texas San Antonio, Dept Cellular & Struct Biol, San Antonio, TX - USA

^[6] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Av Lineu Prestes 1524, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 59, n. 1, p. 362-369, JAN 2018.
• Citações Web of Science: 6

Resumo

PURPOSE: Smith-Magenis syndrome (SMS) causes sleep disturbance that is related to an abnormal melatonin profile. It is not clear how the genomic disorder leads to a disturbed synchronization of the sleep/wake rhythm in SMS patients. To evaluate the integrity of the intrinsically photosensitive retinal ganglion cell (ipRGC)/melanopsin system, the transducers of the light-inhibitory effect on pineal melatonin synthesis, we recorded pupillary light responses (PLR) in SMS patients. METHODS: Subjects were SMS patients (n = 5), with molecular diagnosis and melatonin levels measured for 24 hours and healthy controls (n = 4). Visual stimuli were 1-second red light flashes (640 nm; insignificant direct ipRGC activation), followed by a 470-nm blue light, near the melanopsin peak absorption region (direct ipRGC activation). Blue flashes produce a sustained pupillary constriction (ipRGC driven) followed by baseline return, while red flashes produce faster recovery. RESULTS: Pupillary light responses to 640-nm red flash were normal in SMS patients. In response to 470-nm blue flash, SMS patients had altered sustained responses shown by faster recovery to baseline. SMS patients showed impairment in the expected melatonin production suppression during the day, confirming previous reports. CONCLUSIONS: SMS patients show dysfunction in the sustained component of the PLR to blue light. It could explain their well-known abnormal melatonin profile and elevated circulating melatonin levels during the day. Synchronization of daily melatonin profile and its photoinhibition are dependent on the activation of melanopsin. This retinal dysfunction might be related to a deficit in melanopsin-based photoreception, but a deficit in rod function is also possible. (AU)

• Processo FAPESP: 14/26818-2 - Desenvolvimento e implantação de métodos de avaliação visual: aplicações clínicas e em modelos animais
• Beneficiário: Dora Selma Fix Ventura
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50457-0 - Melatonina e a regulação do metabolismo energético: estudos básicos, clínicos e epidemiológicos
• Beneficiário: José Cipolla Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/06457-5 - Instrumentação científica aplicada aos estudos dos processos visuais desenvolvidos no Laboratório da Visão - IPUSP
• Beneficiário: Dora Selma Fix Ventura
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 15/22227-2 - Avaliação eletrofisiológica e psicofísica das funções visuais: estudo comparativo nas doenças de Alzheimer, neuropatia glaucomatosa e degeneração macular relacionada à idade
• Beneficiário: KALLENE SUMMER MOREIRA VIDAL
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/04538-3 - Distrofinas e o sistema visual humano: estudo dos diferentes fenótipos visuais de pacientes com distrofia muscular de Duchenne
• Beneficiário: Dora Selma Fix Ventura
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/22007-5 - Optimização da capacidade funcional visual de pacientes com maculopatias através de protocolos de treinamento do sistema visual
• Beneficiário: Mirella Telles Salgueiro Barboni
• Modalidade de apoio: Bolsas no Exterior - Pesquisa