Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Characterization of the Gamboa Virus Serogroup (Orthobunyavirus Genus, Peribunyaviridae Family)

Texto completo
Autor(es):
Mostrar menos -
Chiang, Jannifer Oliveira [1] ; de Souza, William Marciel [2, 3] ; Teixeira Nunes, Marcio Roberto [4, 5, 6] ; Acrani, Gustavo Olszanski [7] ; de Andrade Travassos da Rosa, Amelia Paes [4, 5] ; de Freitas, Nelma Mesquita [8] ; da Silva, Sandro Patroca [1] ; Dorta da Silva, Pedro Henrique [1] ; de Sousa, Alana Watanabe [1] ; Rodrigues, Sueli Guerreiro [1] ; Simoes Quaresma, Juarez Antonio [9] ; Dutary, Bedsy [10] ; Guzman, Hilda [4, 5] ; Vasilakis, Nikos [11, 4, 5, 12] ; Tesh, Robert B. [4, 5] ; da Costa Vasconcelos, Pedro Fernando [1]
Número total de Autores: 16
Afiliação do(s) autor(es):
Mostrar menos -
[1] Minist Hlth, Evandro Chagas Inst, Dept Arbovirol & Hemorrhag Fevers, Ananindeua - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, Ribeirao Preto - Brazil
[3] MRC Univ Glasgow Ctr Virus Res, Glasgow, Lanark - Scotland
[4] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 - USA
[5] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 - USA
[6] Minist Hlth, Evandro Chagas Inst, Ctr Technol Innovat, Ananindeua - Brazil
[7] Univ Fed Fronteira Sul, Passo Fundo - Brazil
[8] Ctr Educ Profiss Graziela Reis de Souza, Macapa - Brazil
[9] Univ Fed Para, Trop Med Branch, Belem, Para - Brazil
[10] Gorgas Mem Inst Hlth Studies, Panama City - Panama
[11] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 - USA
[12] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA
Número total de Afiliações: 12
Tipo de documento: Artigo Científico
Fonte: American Journal of Tropical Medicine and Hygiene; v. 98, n. 5, p. 1502-1511, 2018.
Citações Web of Science: 2
Resumo

Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucurui hydroelectric dam in Para state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies. (AU)

Processo FAPESP: 12/24150-9 - Pesquisa de vírus em roedores silvestres, mosquitos e carrapatos
Beneficiário:William Marciel de Souza
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/05778-5 - Análises de bioinformática de dados de metagenômica viral de animais do Brasil e Antártida
Beneficiário:William Marciel de Souza
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado