| Full text | |
| Author(s): Show less - |
Chiang, Jannifer Oliveira
[1]
;
de Souza, William Marciel
[2, 3]
;
Teixeira Nunes, Marcio Roberto
[4, 5, 6]
;
Acrani, Gustavo Olszanski
[7]
;
de Andrade Travassos da Rosa, Amelia Paes
[4, 5]
;
de Freitas, Nelma Mesquita
[8]
;
da Silva, Sandro Patroca
[1]
;
Dorta da Silva, Pedro Henrique
[1]
;
de Sousa, Alana Watanabe
[1]
;
Rodrigues, Sueli Guerreiro
[1]
;
Simoes Quaresma, Juarez Antonio
[9]
;
Dutary, Bedsy
[10]
;
Guzman, Hilda
[4, 5]
;
Vasilakis, Nikos
[11, 4, 5, 12]
;
Tesh, Robert B.
[4, 5]
;
da Costa Vasconcelos, Pedro Fernando
[1]
Total Authors: 16
|
| Affiliation: Show less - | [1] Minist Hlth, Evandro Chagas Inst, Dept Arbovirol & Hemorrhag Fevers, Ananindeua - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, Ribeirao Preto - Brazil
[3] MRC Univ Glasgow Ctr Virus Res, Glasgow, Lanark - Scotland
[4] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 - USA
[5] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 - USA
[6] Minist Hlth, Evandro Chagas Inst, Ctr Technol Innovat, Ananindeua - Brazil
[7] Univ Fed Fronteira Sul, Passo Fundo - Brazil
[8] Ctr Educ Profiss Graziela Reis de Souza, Macapa - Brazil
[9] Univ Fed Para, Trop Med Branch, Belem, Para - Brazil
[10] Gorgas Mem Inst Hlth Studies, Panama City - Panama
[11] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 - USA
[12] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | American Journal of Tropical Medicine and Hygiene; v. 98, n. 5, p. 1502-1511, 2018. |
| Web of Science Citations: | 4 |
| Abstract | |
Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucurui hydroelectric dam in Para state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies. (AU) | |
| FAPESP's process: | 15/05778-5 - Bioinformatics analysis of data of viral metagenomic of animals from Brazil and Antarctica |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships in Brazil - Doctorate |