Bariatric surgery and gene expression in the gut

Autor(es)

Sala, Priscila ^{[1, 2]} ; Correa-Giannella, M. L. ^{[2, 3]} ; Waitzberg, Dan L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Metanutri LIM 35, Dept Gastroenterol, Fac Med, Sao Paulo, SP - Brazil

^[2] Univ Nove de Julho UNINOVE, Programa Posgrad Med, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Carboidratos & Radioimunoensaio LIM 18, Fac Med, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE; v. 21, n. 4, p. 246-251, JUL 2018.
• Citações Web of Science: 0

Resumo

Purpose of reviewThe current review provides an overview of recent literature on new findings related to bariatric surgery and gut gene expression.Recent findingsBariatric surgery modulates the expression of intestinal genes. Experimental and clinical investigations have demonstrated the association of gut rearrangement with changes in intestinal expression of genes related to glucose metabolism. Recent data suggest that bariatric surgery also affects expression of genes belonging to other pathways, including nutrient transporters and metabolism of vitamin B12, decreasing pathway-encoding genes that may contribute to vitamin B12 deficiency in the postoperative period.SummaryBariatric surgery is an effective intervention strategy against severe obesity, resulting in sustained weight loss and reduction of comorbidities. Nutritional genomic changes appear in response to bariatric surgery, possibly due to adaptive gut response. Improved understanding of the molecular pathways modulated by this intervention may facilitate weight and comorbidities management. (AU)

• Processo FAPESP: 11/09612-3 - Alterações na expressão gênica do tecido gástrico e intestinal de portadores de Diabetes melito tipo 2 submetidos à gastroplastia redutora a Y-Roux
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/19170-1 - Alterações na expressão gênica e identificação da assinatura epigenética gastrintestinal relacionadas a resolução precoce e recidiva tardia do Diabetes Tipo 2 em pacientes após 2 anos da derivação gástrica em Y-Roux
• Beneficiário: Priscila Sala Kobal
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado