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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bariatric surgery and gene expression in the gut

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Author(s):
Sala, Priscila [1, 2] ; Correa-Giannella, M. L. [2, 3] ; Waitzberg, Dan L. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Metanutri LIM 35, Dept Gastroenterol, Fac Med, Sao Paulo, SP - Brazil
[2] Univ Nove de Julho UNINOVE, Programa Posgrad Med, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Carboidratos & Radioimunoensaio LIM 18, Fac Med, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE; v. 21, n. 4, p. 246-251, JUL 2018.
Web of Science Citations: 0
Abstract

Purpose of reviewThe current review provides an overview of recent literature on new findings related to bariatric surgery and gut gene expression.Recent findingsBariatric surgery modulates the expression of intestinal genes. Experimental and clinical investigations have demonstrated the association of gut rearrangement with changes in intestinal expression of genes related to glucose metabolism. Recent data suggest that bariatric surgery also affects expression of genes belonging to other pathways, including nutrient transporters and metabolism of vitamin B12, decreasing pathway-encoding genes that may contribute to vitamin B12 deficiency in the postoperative period.SummaryBariatric surgery is an effective intervention strategy against severe obesity, resulting in sustained weight loss and reduction of comorbidities. Nutritional genomic changes appear in response to bariatric surgery, possibly due to adaptive gut response. Improved understanding of the molecular pathways modulated by this intervention may facilitate weight and comorbidities management. (AU)

FAPESP's process: 11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass
Grantee:Dan Linetzky Waitzberg
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/19170-1 - Changes in gene expression and identification of gastrointestinal epigenetic signature related to the early resolution and late recurrence of Type 2 Diabetes after 2 years of Roux-in-Y gastric bypass
Grantee:Priscila Sala Kobal
Support type: Scholarships in Brazil - Post-Doctorate