EVALUATION OF INTESTINAL EXPRESSION OF GENES RELATED TO COPPER AND IRON METABOLISM IN OBESE WOMEN AFTER ROUX-Y GASTRIC BYPASS AND ITS ASSOCIATION WITH DEFICIENCY OF THESE MICRONUTRIENTS

• Grant number: 24/06159-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date until: November 01, 2024
• End date until: July 31, 2025
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Priscila Sala Kobal
• Grantee: Camila Shimizu
• Host Institution: Campus Pompéia. Centro Universitário São Camilo (CUSP). União Social Camiliana (USC). São Paulo , SP, Brazil

Abstract

Bariatric surgery is one of the most effective procedures for the treatment of obesity, highlighting the method of Roux-en-Y gastric bypass (RYGB). The procedure excludes much of the stomach, duodenum and proximal jejunum, thus stimulating satiety, however nutritional deficiencies are not uncommon after surgery, including iron, which can reach 47% of patients and the copper that can reach 4% after 5 years. The RYGB technique excludes from the gastrointestinal tract the main areas of absorption of these micronutrients. Important genes in the metabolism of both have a fall in their expression, for example, ceruloplasmin (CP) is an important gene, as it depends on copper, and the Hefaestine gene (HEPH) the one responsible for the absorption of intestinal iron. Intestinal biopsies of patients submitted to RYGB will be analyzed in the research carried out, to understand changes in gene expressions related to iron and copper metabolism and the cause of deficiency. The study about the expression of genes involved on the metabolism of copper and iron in the intestinal tissue of patients after RYBG can lead us to a better understanding of the potential mechanisms that contribute for the deficiency of these micronutrients.