Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation

Autor(es)

Almeida-Filho, Daniel G. ^[1] ; Queiroz, Claudio M. ^[1] ; Ribeiro, Sidarta ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Norte, Inst Brain, BR-59056450 Natal, RN - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 75, n. 20, p. 3715-3740, OCT 2018.
• Citações Web of Science: 4

Resumo

Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs