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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation

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Author(s):
Almeida-Filho, Daniel G. [1] ; Queiroz, Claudio M. [1] ; Ribeiro, Sidarta [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Rio Grande do Norte, Inst Brain, BR-59056450 Natal, RN - Brazil
Total Affiliations: 1
Document type: Review article
Source: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 75, n. 20, p. 3715-3740, OCT 2018.
Web of Science Citations: 4
Abstract

Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes. (AU)

FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
Grantee:Oswaldo Baffa Filho
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC