Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

Autor(es)

Lorizola, Isabela M. ^[1] ; Furlan, Cibele P. B. ^[2] ; Portovedo, Mariana ^[1] ; Milanski, Marciane ^[1] ; Botelho, Patricia B. ^[3] ; Bezerra, Rosangela M. N. ^[1] ; Sumere, Beatriz R. ^[1] ; Rostagno, Mauricio A. ^[1] ; Capitani, Caroline D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Appl Sci, BR-13484350 Limeira, SP - Brazil

^[2] Univ Estadual Campinas, Dept Food & Nutr DEPAN, Fac Food Engn FEA, BR-13484350 Campinas, SP - Brazil

^[3] Univ Fed Goias, Fac Nutr FANUT, BR-74605080 Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 10, n. 7 JUL 2018.
• Citações Web of Science: 6

Resumo

Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received similar to 5.91 mg of VRE100 g(-1) diet, while the SL groups received similar to 3.07 mg VRE100 g(-1) diet. After 8 weeks, we evaluated fasting blood glucose; cholesterol, hepatic Malondialdehyde (MDA) levels and hepatic Glutathione (GSH), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Superoxide dismutase (SOD) activity. Dehydrated beet stalks and leaves (HFSL) attenuated the deleterious effects of a HF diet on lipid metabolism, reduced fasting blood glucose levels, ameliorated cholesterol levels and reduced GPx and GR activities (p < 0.05) compared to the HF group. However; the addition of ethanolic extract from beet stalks and leaves was unable (p > 0.05) to prevent the liver damage caused by HF diet in mice. The presence of flavonoids, such as Vitexin derivatives in beet stalks and leaves can help the liver damage induced by HF diet. (AU)

• Processo FAPESP: 13/04304-4 - Desenvolvimento de sistemas integrados para a análise de compostos bioativos em produtos naturais utilizando tecnologia supercrítica
• Beneficiário: Maurício Ariel Rostagno
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 15/15035-0 - Avaliação dos parâmetros metabólicos e da gliconeogênese hepática em animais submetidos à dieta controle e hiperlipídica suplementadas com talos e folhas de beterraba (beta vulgaris l.)
• Beneficiário: Caroline Dario Capitani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/18498-5 - Avaliação do efeito de talos e folhas de beterraba (Beta vulgaris L.) no strees oxidativo de animais submetidos a dieta hiperlipídica
• Beneficiário: Isabela Micheletti Lorizola
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica