Combined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopause

Autor(es)

Shimojo, Guilherme Lemos ^[1] ; Dias, Danielle da Silva ^[1] ; Malfitano, Christiane ^[1] ; Sanches, Iris Callado ^[2] ; Llesuy, Susana ^{[1, 3]} ; Ulloa, Luis ^{[1, 4]} ; Irigoyen, Maria-Claudia ^[5] ; De Angelis, Katia ^{[6, 1]}

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo - Brazil

^[2] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[3] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fis Quim, Buenos Aires, DF - Argentina

^[4] Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Surg, Ctr Immunol & Inflammat, Newark, NJ - USA

^[5] Univ Sao Paulo, Heart Inst, Med Sch, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 9, OCT 29 2018.
• Citações Web of Science: 2

Resumo

The prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HRO), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HRO group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy. (AU)

• Processo FAPESP: 18/20419-0 - Treinamento físico aeróbico e resistido combinados melhoram a hipertensão associada a menopausa
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Processo FAPESP: 11/16441-0 - Efeitos do treinamento físico aeróbio ou resistido em parâmetros autonômicos e de estresse oxidativo em ratas hipertensas ooforectomizadas
• Beneficiário: Renata Kelly da Palma
• Modalidade de apoio: Bolsas no Brasil - Mestrado