Lyophilized acai pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells

Autor(es)

Fragoso, Mariana F. ^[1] ; Romualdo, Guilherme R. ^[1] ; Vanderveer, Lisa A. ^[2] ; Franco-Barraza, Janusz ^[3] ; Cukierma, Edna ^[3] ; Clapper, Margie L. ^[2] ; Carvalho, Robson F. ^[4] ; Barbisa, Luis F. ^[4]

Afiliação do(s) autor(es)

^[1] UNESP, Dept Pathol, Botucatu Med Sch, Botucatu, SP - Brazil

^[2] Fox Chase Canc Ctr, Canc Prevent & Control Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA

^[3] Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA

^[4] UNESP, Dept Morphol, Inst Biosci Botucatu, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food and Chemical Toxicology; v. 121, p. 237-245, NOV 2018.
• Citações Web of Science: 5

Resumo

This study evaluated the possible protective effects of lyophilized acai pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 mu M) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity. (AU)

• Processo FAPESP: 13/17600-0 - Efeitos da ingestão da polpa de açaí liofilizada (Euterpe oleracea Mart) no processo de carcinogênese química em ratos wistar
• Beneficiário: Mariana Franco Fragoso
• Modalidade de apoio: Bolsas no Brasil - Doutorado