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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lyophilized acai pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells

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Author(s):
Fragoso, Mariana F. [1] ; Romualdo, Guilherme R. [1] ; Vanderveer, Lisa A. [2] ; Franco-Barraza, Janusz [3] ; Cukierma, Edna [3] ; Clapper, Margie L. [2] ; Carvalho, Robson F. [4] ; Barbisa, Luis F. [4]
Total Authors: 8
Affiliation:
[1] UNESP, Dept Pathol, Botucatu Med Sch, Botucatu, SP - Brazil
[2] Fox Chase Canc Ctr, Canc Prevent & Control Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA
[3] Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA
[4] UNESP, Dept Morphol, Inst Biosci Botucatu, Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Food and Chemical Toxicology; v. 121, p. 237-245, NOV 2018.
Web of Science Citations: 5
Abstract

This study evaluated the possible protective effects of lyophilized acai pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying effect of cyanidin 3-rutinoside (C3R) on the motility of RKO colon adenocarcinoma cells, using the wound healing assay. Male Wistar rats were induced to develop CAC using 1,2-dimethylhydrazine (DMH) and 2,4,6-trinitrobenzene acid (TNBS). Animals were randomly assigned to different groups that received basal diet or basal diet supplemented with 5.0% or 7.5% lyophilized AP. The findings indicate: 1) C3R (25 mu M) has the potential to reduce RKO cell motility in vitro; 2) ingestion of lyophilized AP reduces the total number of aberrant crypt foci (ACF), ACF multiplicity, tumor cell proliferation and incidence of tumors with high grade dysplasia; 3) AP increases the gene expression of negative regulators of cell proliferation such as Dlc1 and Akt3, as well as inflammation (Ppara). Thus, lyophilized AP could exert a potential antitumor activity. (AU)

FAPESP's process: 13/17600-0 - Effects of lyophilized açaí pulp (Euterpe oleraceae Mart) in the process of chemical carcinogenesis
Grantee:Mariana Franco Fragoso
Support Opportunities: Scholarships in Brazil - Doctorate