IN VITRO Anticancer Activity and Physicochemical Properties of SOLANUM LYCOCARPUM Alkaloidic Extract Loaded in Natural Lipid-Based Nanoparticles

Autor(es)

Carvalho, I. P. S. ^[1] ; Miranda, M. A. ^[1] ; Silva, L. B. ^[1] ; Chrysostomo-Massaro, T. N. ^[1] ; Paschoal, J. A. R. ^[2] ; Bastos, J. K. ^[2] ; Marcato, P. D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, NanoBioLab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COLLOID AND INTERFACE SCIENCE COMMUNICATIONS; v. 28, p. 5-14, JAN 2019.
• Citações Web of Science: 3

Resumo

Bladder cancer (BC) is the 9th most common cancer in the worldwide. BC's treatment is still a challenging goal. Thereby, the screening of natural compounds as solasonine (SS) and solamargine (SM) that exhibit antitumor activity is interesting to BC therapy. This work aimed to develop natural lipid-based nanoparticles (NLN) as carrier system of S. lycocarpum's fruits alkaloidic extract (AE), rich in SS and SM, and to evaluate its antitumor activity in bladder cancer cells. The NLN-AE exhibited 56 nm of diameter, low polydispersity index with shelf life estimated of 12 months, measured by LUMiSizer (R). NLN-AE showed low recrystallization index with high encapsulation efficiency of SS (86%) and SM (89%). A sustained release profile was verified after 36 h. The free AE exhibited antitumor activity in bladder cancer cells. The cell viability decreased 5.4 fold when AE was encapsulated in NLN. Thus, NLN-AE has higher anti-proliferative activity than the free AE. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/50762-1 - Estudo comparativo dos efeitos do imunomodulador P-MAPA encapsulado em nanopartículas poliméricas mucoadesivas versus imunoterapia com BCG na progressão do câncer de bexiga urinária: avaliação histopatológica e molecular
• Beneficiário: Priscyla Daniely Marcato Gaspari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/16727-0 - Desenvolvimento de nanopartículas lipídicas sólidas no carreamento de glicoalcalóides de Solanum lycocarpum para terapia do câncer de bexiga
• Beneficiário: Ivana Pereira Santos Carvalho
• Modalidade de apoio: Bolsas no Brasil - Mestrado