Fungal Biofilms and Polymicrobial Diseases

Autor(es):Mostrar menos -

Costa-Orlandi, Caroline B. ^[1] ; Sardi, Janaina C. O. ^[2] ; Pitangui, Nayla S. ^[1] ; de Oliveira, Haroldo C. ^[1] ; Scorzoni, Liliana ^[1] ; Galeane, Mariana C. ^[1] ; Medina-Alarcon, Kaila P. ^[1] ; Melo, Wanessa C. M. A. ^[1] ; Marcelino, Monica Y. ^[1] ; Braz, Jaqueline D. ^[1] ; Fusco-Almeida, Ana Marisa ^[1] ; Mendes-Giannini, Maria Jose S. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, UNICAMP, BR-13414018 Piracicaba, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF FUNGI; v. 3, n. 2 JUN 2017.
• Citações Web of Science: 18

Resumo

Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized communities that are resistant to antimicrobials and environmental conditions. In recent years, new genera of fungi have been correlated with biofilm formation. However, Candida biofilms remain the most widely studied from the morphological and molecular perspectives. Biofilms formed by yeast and filamentous fungi present differences, and studies of polymicrobial communities have become increasingly important. A key feature of resistance is the extracellular matrix, which covers and protects biofilm cells from the surrounding environment. Furthermore, to achieve cell-cell communication, microorganisms secrete quorum-sensing molecules that control their biological activities and behaviors and play a role in fungal resistance and pathogenicity. Several in vitro techniques have been developed to study fungal biofilms, from colorimetric methods to omics approaches that aim to identify new therapeutic strategies by developing new compounds to combat these microbial communities as well as new diagnostic tools to identify these complex formations in vivo. In this review, recent advances related to pathogenic fungal biofilms are addressed. (AU)

• Processo FAPESP: 15/03700-9 - Animais alternativos aplicados à interação Paracoccidioides-hospedeiro para o desenvolvimento de estudos de virulência, eficácia e toxicidade de compostos antifúngicos e tratamentos preventivos
• Beneficiário: Maria José Soares Mendes Giannini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/14023-8 - Uso de peptídeos com atividade anti-adesiva em Paracoccidoides spp. na terapêutica e profilaxia da paracoccidioidomicose
• Beneficiário: Haroldo Cesar de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/10917-9 - Modelos animais alternativos: Virulência de diferentes espécies filogenéticas de Paracoccidioides e efeito das proteínas 43kDa e 30kDa e de seus anticorpos
• Beneficiário: Liliana Scorzoni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/11836-0 - SELEÇÃO DE ALVOS TERAPÊUTICOS E/OU BIOMARCADORES A PARTIR DA RESPOSTA TRANSCRICIONAL GLOBAL DA INFECÇÃO DE MACRÓFAGOS ALVEOLARES POR BIOFILMES DE H. capsulatum
• Beneficiário: Ana Marisa Fusco Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular